Objective:　To　establish　and　evaluate　the　heart　failure　model　induced　by　volume　and　pressure　overload　in　New　Zealand　rabbits.　Methods:　Thirty-seven　New　Zealand　rabbits　were　randomly　divided　into　the　heart　failure　group　and　the　control　group.　The　former　group　was　subdivided　into　three　groups.　The　volume　overload　group　had　rupture　of　the　aortic　valve,　the　pressure　overload　group　was　created　by　a　suprarenal　stenosis　of　50%　of　the　abdominal　aorta,　and　the　combination　group　underwent　both　operations.　Control　group　only　had　dissection　of　arteries.　Hemodynamic　and　echocardiographic　characteristics　and　BNP　level　were　evaluated　8　weeks　after　the　operation.　Results:　Hemodynamic　results　showed　that　heart　rate,　aortic　systolic　pressure,　aortic　diastolic　pressure,　pulse　pressure,　left　ventricular　end　systolic　pressure　and　left　ventricular　end　diastolic　pressure　were　significantly　higher　in　the　combination　group　than　in　the　other　groups　(all　P＜0.05).　Echocardiographic　results　indicated　that　left　ventricular　end　diastolic　diameter,　left　ventricular　end　systolic　diameter,　interventricular　septum　thickness,　left　ventricular　posterior　wall　thickness,　fraction　shortening　(FS),　and　E/A　ratio　were　significantly　higher　in　the　combination　group　than　in　the　control　group　(P＜0.05)　,　and　EF　was　significantly　lower　than　in　the　other　groups　(all　P＜0.05).　BNP　concentration　of　rabbits　in　the　combination　group　significantly　increased　compared　with　that　in　the　other　groups　(all　P＜0.05).　Heart　weight　/body　weight　and　lung　weight/body　weight　in　the　combination　group　were　significantly　higher　than　those　in　the　other　groups　(all　P＜0.05).　Conclusion:　The　animal　heart　failure　model　induced　by　volume　and　pressure　overload　can　be　easily　established.　Pressure　overload　and　volume　overload　have　different　effects　on　the　cardiac　function.