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Author:

Liang, Yongping (Liang, Yongping.) | Zhao, Xin (Zhao, Xin.) | Hu, Tianli (Hu, Tianli.) | Chen, Baojun (Chen, Baojun.) | Yin, Zhanhai (Yin, Zhanhai.) | Ma, Peter X. (Ma, Peter X..) | Guo, Baolin (Guo, Baolin.)

Indexed by:

SCIE EI Scopus PubMed

Abstract:

Developing injectable nanocomposite conductive hydrogel dressings with multifunctions including adhesiveness, antibacterial, and radical scavenging ability and good mechanical property to enhance full-thickness skin wound regeneration is highly desirable in clinical application. Herein, a series of adhesive hemostatic antioxidant conductive photothermal antibacterial hydrogels based on hyaluronic acid-graft-dopamine and reduced graphene oxide (rGO) using a H2O2/HPR (horseradish peroxidase) system are prepared for wound dressing. These hydrogels exhibit high swelling, degradability, tunable rheological property, and similar or superior mechanical properties to human skin. The polydopamine endowed antioxidant activity, tissue adhesiveness and hemostatic ability, self-healing ability, conductivity, and NIR irradiation enhanced in vivo antibacterial behavior of the hydrogels are investigated. Moreover, drug release and zone of inhibition tests confirm sustained drug release capacity of the hydrogels. Furthermore, the hydrogel dressings significantly enhance vascularization by upregulating growth factor expression of CD31 and improve the granulation tissue thickness and collagen deposition, all of which promote wound closure and contribute to a better therapeutic effect than the commercial Tegaderm films group in a mouse full-thickness wounds model. In summary, these adhesive hemostatic antioxidative conductive hydrogels with sustained drug release property to promote complete skin regeneration are an excellent wound dressing for full-thickness skin repair.

Keyword:

adhesive conductive hydrogels antioxidant drug release hemostat wound healing

Author Community:

  • [ 1 ] [Liang, Yongping; Zhao, Xin; Hu, Tianli; Guo, Baolin] Xi An Jiao Tong Univ, Frontier Inst Sci & Technol, Xian 710049, Shaanxi, Peoples R China
  • [ 2 ] [Liang, Yongping; Zhao, Xin; Hu, Tianli; Guo, Baolin] Xi An Jiao Tong Univ, State Key Lab Mech Behav Mat, Xian 710049, Shaanxi, Peoples R China
  • [ 3 ] [Chen, Baojun; Yin, Zhanhai] Xi An Jiao Tong Univ, Dept Orthopaed, Affiliated Hosp 1, Coll Med, Xian 710061, Shaanxi, Peoples R China
  • [ 4 ] [Ma, Peter X.] Univ Michigan, Macromol Sci & Engn Ctr, Ann Arbor, MI 48109 USA
  • [ 5 ] [Ma, Peter X.] Univ Michigan, Dept Mat Sci & Engn, Ann Arbor, MI 48109 USA
  • [ 6 ] [Guo, Baolin] Xi An Jiao Tong Univ, Coll Stomatol, Key Lab Shaanxi Prov Craniofacial Precis Med Res, Xian 710049, Shaanxi, Peoples R China
  • [ 7 ] [Liang, Yongping]Xi An Jiao Tong Univ, Frontier Inst Sci & Technol, Xian 710049, Shaanxi, Peoples R China
  • [ 8 ] [Zhao, Xin]Xi An Jiao Tong Univ, Frontier Inst Sci & Technol, Xian 710049, Shaanxi, Peoples R China
  • [ 9 ] [Hu, Tianli]Xi An Jiao Tong Univ, Frontier Inst Sci & Technol, Xian 710049, Shaanxi, Peoples R China
  • [ 10 ] [Guo, Baolin]Xi An Jiao Tong Univ, Frontier Inst Sci & Technol, Xian 710049, Shaanxi, Peoples R China
  • [ 11 ] [Liang, Yongping]Xi An Jiao Tong Univ, State Key Lab Mech Behav Mat, Xian 710049, Shaanxi, Peoples R China
  • [ 12 ] [Zhao, Xin]Xi An Jiao Tong Univ, State Key Lab Mech Behav Mat, Xian 710049, Shaanxi, Peoples R China
  • [ 13 ] [Hu, Tianli]Xi An Jiao Tong Univ, State Key Lab Mech Behav Mat, Xian 710049, Shaanxi, Peoples R China
  • [ 14 ] [Guo, Baolin]Xi An Jiao Tong Univ, State Key Lab Mech Behav Mat, Xian 710049, Shaanxi, Peoples R China
  • [ 15 ] [Chen, Baojun]Xi An Jiao Tong Univ, Dept Orthopaed, Affiliated Hosp 1, Coll Med, Xian 710061, Shaanxi, Peoples R China
  • [ 16 ] [Yin, Zhanhai]Xi An Jiao Tong Univ, Dept Orthopaed, Affiliated Hosp 1, Coll Med, Xian 710061, Shaanxi, Peoples R China
  • [ 17 ] [Ma, Peter X.]Univ Michigan, Macromol Sci & Engn Ctr, Ann Arbor, MI 48109 USA
  • [ 18 ] [Ma, Peter X.]Univ Michigan, Dept Mat Sci & Engn, Ann Arbor, MI 48109 USA
  • [ 19 ] [Guo, Baolin]Xi An Jiao Tong Univ, Coll Stomatol, Key Lab Shaanxi Prov Craniofacial Precis Med Res, Xian 710049, Shaanxi, Peoples R China

Reprint Author's Address:

  • Xi An Jiao Tong Univ, Frontier Inst Sci & Technol, Xian 710049, Shaanxi, Peoples R China.; Guo, BL (reprint author), Xi An Jiao Tong Univ, State Key Lab Mech Behav Mat, Xian 710049, Shaanxi, Peoples R China.; Guo, BL (reprint author), Xi An Jiao Tong Univ, Coll Stomatol, Key Lab Shaanxi Prov Craniofacial Precis Med Res, Xian 710049, Shaanxi, Peoples R China.

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Source :

SMALL

ISSN: 1613-6810

Year: 2019

Issue: 12

Volume: 15

1 1 . 4 5 9

JCR@2019

1 3 . 2 8 1

JCR@2020

ESI Discipline: MATERIALS SCIENCE;

ESI HC Threshold:131

JCR Journal Grade:4

CAS Journal Grade:2

Cited Count:

WoS CC Cited Count: 557

SCOPUS Cited Count: 1068

ESI Highly Cited Papers on the List: 19 Unfold All

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WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 2

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