Alcoholic　liver　disease　(ALD),　as　one　of　the　most　common　diseases,　has　become　a　global　threat　to　human　health.　The　aim　of　this　study　was　designed　to　investigate　the　hepatoprotective　effects　of　ginsenoside　Rk3　against　ALD　and　to　discover　the　potential　mechanisms　of　these　protective　effects.　Mice　were　intragastrically　administered　50%　alcohol　and　treated　with　ginsenoside　Rk3　(25　and　50　mg/kg)　once　per　day　for　6　weeks.　The　results　indicated　that　ginsenoside　Rk3　promoted　hepatic　function　through　significant　downgrading　AST　and　ALT　levels　in　the　serum,　attenuating　oxidative　stress,　and　restoring　antioxidant　balance　in　hepatic　tissue.　Additionally,　ginsenoside　Rk3　significantly　reduced　the　expression　of　inflammatory　cytokines,　such　as　NF-kappa　B,　TNF-alpha,　IL-6,　and　IL-1　beta　in　the　mice.　Furthermore,　ginsenoside　Rk3　supplementation　significantly　inhibited　apoptotic　protein　expression　in　the　liver.　The　present　study　clearly　demonstrates　that　ginsenoside　Rk3　exerts　a　protective　effect　against　ALD-induced　liver　injury　because　of　its　antioxidant,　anti-apoptotic,　and　anti-inflammatory　activities.　The　findings　from　the　present　investigation　show　that　ginsenoside　Rk3　might　be　a　promising　candidate　treatment　agent　against　ALD.