Chronic　obstructive　pulmonary　disease　(COPD)　is　the　fourth　leading　cause　of　death　nowadays,　and　its　under-diagnosis　is　still　a　great　challenge.　More　effective　diagnosis　method　is　in　urgent　need　since　the　traditional　spirometry　has　many　limitations　in　the　practical　application.　The　electrochemical　(EC)　detection　methods　have　their　unique　advantages　of　high　accuracy,　short　response　time　and　easy　integration　of　the　system.　In　this　review,　recent　works　on　the　EC　methods　for　COPD　biomarkers　including　interleukin　6　(IL-6),　interleukin　8　(IL-8)　and　Creactive　protein　(CRP)　are　summarized.　Five　types　of　EC　methods　are　highlighted　in　this　study,　as　enzyme-labelled　immunosensors,　nanoparticle-labelled　immunosensors,　capacitive　or　impedimetric　immunosensors,　magnetoimmunosensors,　and　field　effect　transistor　(FET)　immunosensors.　To　date,　EC　immunosensors　have　been　exhibiting　high　analytical　performance　with　a　detection　limit　that　can　achieve　several　pg/mL　or　even　lower.　The　simplicity　of　EC　immunosensors　makes　them　a　perfect　solution　for　a　future　point-of-care　device　to　use　in　settings　for　COPD　diagnosis　and　follow-up.　Nevertheless,　more　efforts　need　to　be　paid　on　the　simultaneous　detection　of　multiple　biomarkers,　a　demand　for　the　clinical　diagnosis,　and　processes　of　assay　simplification　towards　achieving　one-step　detection.