In　this　work,　the　coupling　phase　change　heat　transfer　process　and　thermal　stress　behavior　of　biological　tissue　during　cryosurgery　are　studied　in　the　context　of　a　generalized　thermoelastic　theory.　The　nonlinear　governing　equations　are　constructed　while　considering　the　variable　thermal　properties　and　solved　by　a　time-domain　finite　element　method　based　on　the　effective　heat　capacity　formulation.　A　2-D　tumor　and　normal　tissue　model　is　adopted　for　simulating　the　freezing　process　in　cryosurgery.　The　effects　of　temperature-dependent　thermal　properties　and　relaxation　time　on　the　responses　of　biological　tissue　are　discussed　and　illustrated　graphically.