A　comprehensive　study　of　Fe　alloying　influence　on　as-cast　titanium　alloys,　including　microstructure,　mechanical　properties,　bio-corrosion　behavior　and　in-vitro　cell　response　have　been　carried　out　to　evaluate　the　biological　application　potential　of　Ti-Fe　binary　alloys.　The　results　indicate　that　grain　sizes　of　as-cast　Ti-Fe　alloys　are　remarkably　refined　with　Fe　addition　and　the　mechanical　strength　is　increased　tremendously.　For　instance,　Ti-2Fe　alloy　presents　excellent　mechanical　properties　by　elevating　the　tensile　strength　to　566　MPa,　or　1.5　times　over　pure　Ti,　while　maintaining　a　relative　high　plasticity.　All　Ti-Fe　alloys　carried　in　this　study　show　a　higher　corrosion　resistance　in　Hank＇s　solution　than　pure　Ti　due　to　the　grain　refine　enhancement　and　higher　oxide　film　growth　kinetics.　Ti-2Fe　alloy　presents　the　best　corrosion　resistance　among　them　and　higher　Fe　content　could　bring　more　Fe2O3　to　the　oxidation　films　that　decrease　the　corrosion　resistance　accordingly.　All　Ti-Fe　alloys　are　holding　a　similar　osteoblast　cell　viability　and　response　to　pure　Ti　which　ensure　their　biocompatibility.　The　combination　of　mechanical　properties,　corrosion　resistance　and　in-vitro　response　of　Ti-2Fe　promised　its　application　as　dental　implants　in　a　near　future.　©　2021　Elsevier　B.V.