Panax　ginseng，as　a　well-known　medical　plant　with　economic　value，has　a　long　history　of　use　for　treating　various　diseases　in　Asian.　Accumulating　clinical　and　experimental　evidences　suggest　that　ginsenoside　Rb1，which　is　the　major　bioactive　components　of　the　plant,　have　a　variety　of　biological　effects　on　treating　aging　related　diseases　such　as:　cardiovascular　disease　(CVD),　central　nervous　system　disease　(CNSD),　and　osteoporosis　(OP).　Recently,　considerable　attentions　have　been　focused　on　ginsenoside　Rb1　as　an　anti-osteoporosis　agent.　It　has　been　reported　that　ginsenoside　Rb1　could　promote　osteoblast　differentiation　by　up-regulating　the　expression　of　RNUX2　protein　/　regulating　the　Wnt　/　βcatenin　signaling　pathway.　Besides　that,　studies　also　demonstrated　that　ginsenoside　Rb1　could　inhibit　the　NF-κB　receptor　activation　(RANKL)　activity,　thereby　achieving　the　curative　effect　of　preventing　osteoporosis.　Therefore,　this　article　aim　to　review　the　research　progress　of　the　mechanism　of　ginsenoside　Rb1　in　preventing　and　treating　osteoporosis,　with　a　view　to　providing　reference　for　further　research　on　the　anti-osteoporosis　effect　of　this　natural　compound.