Objective:　Composites　with　remineralizing　and　antibacterial　properties　are　favorable　for　caries　inhibition.　The　objectives　of　this　study　were　to　develop　a　new　bioactive　nanocomposite　with　remineralizing　and　antibiofilm　properties　by　incorporating　dimethylaminohexadecyl　methacrylate　(DMAHDM)　and　nano-calcium　fluoride　(nCaF2)　.　Methods:　nCaF2　was　produced　via　a　spray-drying　method　and　integrated　at　15%　mass　fraction　into　composite.　DMAHDM　was　added　at　3%　mass　fraction.　Mechanical　properties　and　F　and　Ca　ion　releases　were　assessed.　Colony-forming　units　(CFU),　lactic　acid　and　metabolic　activity　of　biofilms　on　composites　were　performed.　Results:　The　new　composites　had　flexural　strengths　of　(95.28　+/-　6.32)　MPa　and　(125.93　+/-　7.49)　MPa,　which　were　within　the　ISO　recommendations.　Biofilm　CFU　were　reduced　by　3-4　log　(p＜0.05).　The　composites　achieved　high　F　releases　of　(0.89　+/-　0.01)　mmol/L　and　(0.44　+/-　0.01)　mmol/L,　and　Ca　releases　of　(1.46　+/-　0.05)　mmol/L　and　(0.54　+/-　0.005)　mmol/L.　Conclusions:　New　nanocomposites　were　developed　with　good　mechanical　properties,　potent　antibacterial　activity　against　salivary　biofilms,　and　high　F　and　Ca　ion　releases　with　potential　for　remineralization.　Clinical　Significance:　Novel　nanocomposites　using　nCaF2　and　DMAHDM　were　developed　with　potent　antibacterial　and　remineralizing　effects　and　high　F　and　Ca　ion　releases.　They　are　promising　to　inhibit　recurrent　caries,　promote　remineralization,　and　possess　long-term　sustainability.