The　pressure　pulsation　excited　by　the　variation　of　fluid　flow　rate　is　usually　uncertain　for　pipes　conveying　fluid,　which　poses　a　serious　threat　to　the　security　of　the　pipeline　system.　Considering　the　fluid-structure　interaction　effect,　an　efficient　and　accurate　method　for　predicting　the　stochastic　dynamic　behavior　of　pipe-conveying　fluid　under　uncertain　pressure　pulsation　is　proposed　in　this　paper.　In　this　method,　the　matrix　inversion　of　pipeline　structure　is　calculated　only　once　for　all　time　steps　and　samples　by　utilizing　the　Neumann　expansion　strategy　within　the　framework　of　the　Monte　Carlo　simulation.　In　each　time　step,　the　fluid　transient　characteristics　in　pipe　are　acquired　by　the　method　of　characteristics　(MOC)　and　the　dynamic　responses　of　pipe　structure　are　obtained　by　the　finite　element　method　(FEM).　An　experiment　platform　consisting　of　a　three-plunger　reciprocating　pump　and　a　liquid-filled　piping　system　is　established　to　validate　the　proposed　method.　By　the　comparisons　of　statistical　dynamic　responses,　the　results　obtained　by　the　proposed　method　show　good　agreement　with　the　experimental　data　and　the　direct　Monte　Carlo　simulation　results,　which　indicates　that　the　proposed　method　can　predict　the　stochastic　dynamic　response　of　pipe-conveying　fluid　with　efficiency　and　accuracy.　©　＇Advances　in　Acoustics,　Noise　and　Vibration　-　2021＇　Proceedings　of　the　27th　International　Congress　on　Sound　and　Vibration,　ICSV　2021.　All　rights　reserved.