Search　of　nuclear　structural　materials　with　excellent　comprehensive　properties　is　one　of　the　significant　challenges　in　advanced　reactor　development.　Refractory　high　entropy　alloys　(RHEAs),　which　have　bodycentered　cubic　structures　and　contain　multiple　refractory　elements　as　major　alloying　elements,　have　great　advantages　on　irradiation　tolerance　and　high-temperature　strength,　and　thus　are　promising　candidates　for　nuclear　structural　materials.　In　this　review,　the　research　progress　of　RHEAs　for　nuclear　applications　is　summarized　from　aspects　of　alloy　design　and　fabrication,　phase　structure　and　phase　stability,　mechanical　property,　corrosion　resistance,　as　well　as　radiation　resistance.　The　future　research　directions　and　potential　nuclear　application　scenarios　of　RHEAs　are　also　presented.　©　2022　Cailiao　Daobaoshe/　Materials　Review.　All　rights　reserved.