Background/Aims:　Excess　dietary　salt　is　a　critical　risk　factor　of　salt-sensitive　hypertension.　Glucagon-like　peptide-1　(GLP-1),　a　gut　incretin　hormone,　conferring　benefits　for　blood　pressure　by　natriuresis　and　diuresis.　We　implemented　a　randomized　trial　to　verify　the　effect　of　altered　salt　intake　on　serum　GLP-1　level　in　human　beings.　Methods:　The　38　subjects　were　recruited　from　a　rural　community　of　Northern　China.　All　subjects　were　sequentially　maintained　a　baseline　diet　period　for　3　days,　a　low-salt　diet　period　for　7　days　(3.0g/day　of　NaCl),　and　a　high-salt　diet　period　for　additional　7　days　(18.0g/day　of　NaCl).　Results:　Serum　GLP-1　level　increased　significantly　with　the　change　from　the　baseline　period　to　the　low-salt　diet　period　and　decreased　with　the　change　from　the　low-salt　to　high-salt　diet　in　normotensive　salt-sensitive　(SS)　but　not　salt-resistant　(SR)　individuals.　There　was　a　significant　inverse　correlation　between　the　serum　GLP-1　level　and　the　MAP　in　SS　subjects.　Inverse　correlation　between　the　serum　GLP-1　level　and　24-h　urinary　sodium　excretion　was　also　found　among　different　dietary　interventions　in　SS　subjects.　Conclusions:　Our　study　indicates　that　variations　in　dietary　salt　intake　affect　the　serum　GLP-1　level　in　normotensive　salt-sensitive　Chinese　adults.　(C)　2017　The　Author(s)　Published　by　S.　Karger　AG,　Basel