Injectable　hydrogels　with　multistimuli　responsiveness　to　electrical　field　and　pH　as　a　drug　delivery　system　have　been　rarely　reported.　Herein,　we　developed　a　series　of　injectable　conductive　hydrogels　as　＂smart＂　drug　carrier　with　the　properties　of　electro-responsiveness,　pH　-sensitivity,　and　inherent　antibacterial　activity.　The　hydrogels　were　prepared　by　mixing　chitosan-graft-polyaniline　(CP)　copolymer　and　oxidized　dextran　(OD)　as　a　cross-linker.　The　chemical　structures,　morphologies,　electrochemical　property,　swelling　ratio,　conductivity,　rheological　property,　in　vitro　and　in　vivo　biodegradation,　and　gelation　time　of　hydro　gels　were　characterized.　The　pH-responsive　behavior　was　verified　by　drug　release　from　hydrogels　in　PBS　solutions　with　different　pH　values　(pH　=　7.4　or　5.5)　in　an　in　vitro　model.　As　drug　carriers　with　electric　driven　release,　the　release　rate　of　the　model　drugs　amoxicillin　and　ibuprofen　loaded　within　CP/OD　hydro　gels　dramatically　increased　when　an　increase　in　voltage　was　applied.　Both　chitosan　and　polyaniline　with　inherent　antibacterial　properties　endowed　the　hydrogels　with　excellent　antibacterial　properties.　Furthermore,　cytotoxicity　tests　of　the　hydrogels　using　L929　cells　confirmed　their　good　cytocompatibility.　The　in　vivo　biocompatibility　of　the　hydrogels　was　verified　by　H&E　staining.　Together,　all　these　results　suggest　that　these　injectable　pH-sensitive　conductive　hydrogels　with　antibacterial　activity　could　be　ideal　candidates　as　smart　drug　delivery　vehicles　for　precise　doses　of　medicine　to　meet　practical　demand.　Statement　of　Significance　Stimuli-responsive　or　＂smart＂　hydrogels　have　attracted　great　attention　in　the　field　of　biotechnology　and　biomedicine,　especially　on　designing　novel　drug　delivery　systems.　Compared　with　traditional　implantable　electronic　delivery　devices,　the　injectable　hydrogels　with　electrical　stimuli　not　only　are　easy　to　generate　and　control　electrical　field　but　also　could　avoid　frequent　invasive　surgeries　that　offer　a　new　avenue　for　chronic　diseases.　In　addition,　designing　a　drug　carrier　with　pH-sensitive　property　could　release　drug　efficiently　in　targeted　acid　environment,　and　it　could　reinforce　the　precise　doses　of　medicine.　Furthermore,　caused　by　opportunistic　microorganisms　and　rapid　spread　of　antibiotic-resistant　microbes,　infection　is　still　a　serious　threat　for　many　clinical　utilities.　To　overcome　these　barriers,　we　designed　a　series　of　injectable　antibacterial　conductive　hydrogels　based　on　chitosan-graft-polyaniline　(CP)　copolymer　and　oxidized　dextran　(OD),　and　we　demonstrated　their　potential　as　＂smart＂　delivery　vehicles　with　electro-responsiveness　and　pH-responsive　properties　for　triggered　and　localized　release　of　drugs.　(C)　2018　Acta　Materialia　Inc.　Published　by　Elsevier　Ltd.　All　rights　reserved.