Developing　new　methods　to　treat　heart　diseases　is　always　a　focus　for　basic　research　and　clinical　applications.　Existing　drugs　have　strong　side-effects　and　also　require　lifetime　administration　for　patients.　Recent　attempts　of　using　nanoparticles　(NPs)　in　treating　atherosclerosis　in　animals　and　some　heart　diseases　such　as　heart　failure　and　endocarditis　have　provided　hopes　for　better　drug　delivery　and　reducing　of　drug　side-effects.　In　this　mini-review,　we　summarize　the　present　applications　of　using　gold　nanoparticles　(GNPs)　as　a　new　drug　delivery　system　in　diseased　hearts　and　of　the　assessment　of　toxicity　in　using　GNPs.　We　suggest　that　conjugating　existing　clinical　drugs　with　GNPs　is　a　favorable　choice　to　provide　＂new　and　double-enhanced＂　potentiality　to　those　existing　drugs　in　treating　heart　diseases.　Other　applications　of　using　NPs　in　the　treatment　of　heart　diseases　including　using　drugs　in　nano-form　and　coating　drugs　with　a　surface　of　relevant　NP　are　also　discussed.