• Complex
  • Title
  • Author
  • Keyword
  • Abstract
  • Scholars
Search

Author:

Qu, Jin (Qu, Jin.) | Zhao, Xin (Zhao, Xin.) | Liang, Yongping (Liang, Yongping.) | Zhang, Tianlong (Zhang, Tianlong.) | Ma, Peter X. (Ma, Peter X..) | Guo, Baolin (Guo, Baolin.)

Indexed by:

SCIE PubMed EI Scopus

Abstract:

Designing wound dressing materials with outstanding therapeutic effects, self-healing, adhesiveness and suitable mechanical property has great practical significance in healthcare, especially for joints skin wound healing. Here, we designed a kind of self-healing injectable micelle/hydrogel composites with multi-functions as wound dressing for joint skin damage. By combining the dynamic Schiff base and copolymer micelle cross-linking in one system, a series of hydrogels were prepared by mixing quaternized chitosan (QCS) and benzaldehyde-terminated Pluronic (center dot)F127 (PF127-CHO) under physiological conditions. The inherent antibacterial property, pH-dependent biodegradation and release behavior were investigated to confirm multi-functions of wound dressing. The hydrogel dressings showed suitable stretchable and compressive property, comparable modulus with human skin, good adhesiveness and fast self-healing ability to bear deformation. The hydrogels exhibited efficient hemostatic performance and biocompatibility. Moreover, the curcumin loaded hydrogel showed good antioxidant ability and pH responsive release profiles. In vivo experiments indicated that curcumin loaded hydrogels significantly accelerated wound healing rate with higher granulation tissue thickness and collagen disposition and upregulated vascular endothelial growth factor (VEGF) in a full-thickness skin defect model. Taken together, the antibacterial adhesive hydrogels with self-healing and good mechanical property offer significant promise as dressing materials for joints skin wound healing.

Keyword:

Adhesive Antibacterial activity Curcumin Hemostat Injectable self-healing hydrogel Wound dressing

Author Community:

  • [ 1 ] [Qu, Jin; Zhao, Xin; Liang, Yongping; Zhang, Tianlong; Guo, Baolin] Xi An Jiao Tong Univ, Frontier Inst Sci & Technol, Xian 710049, Peoples R China
  • [ 2 ] [Qu, Jin; Zhao, Xin; Liang, Yongping; Zhang, Tianlong; Guo, Baolin] Xi An Jiao Tong Univ, State Key Lab Mech Behav Mat, Xian 710049, Peoples R China
  • [ 3 ] [Ma, Peter X.] Univ Michigan, Dept Biomed Engn, Ann Arbor, MI 48109 USA
  • [ 4 ] [Ma, Peter X.] Univ Michigan, Dept Biol & Mat Sci, Ann Arbor, MI 48109 USA
  • [ 5 ] [Ma, Peter X.] Univ Michigan, Macromol Sci & Engn Ctr, Ann Arbor, MI 48109 USA
  • [ 6 ] [Ma, Peter X.] Univ Michigan, Dept Mat Sci & Engn, Ann Arbor, MI 48109 USA
  • [ 7 ] [Qu, Jin]Xi An Jiao Tong Univ, Frontier Inst Sci & Technol, Xian 710049, Peoples R China
  • [ 8 ] [Zhao, Xin]Xi An Jiao Tong Univ, Frontier Inst Sci & Technol, Xian 710049, Peoples R China
  • [ 9 ] [Liang, Yongping]Xi An Jiao Tong Univ, Frontier Inst Sci & Technol, Xian 710049, Peoples R China
  • [ 10 ] [Zhang, Tianlong]Xi An Jiao Tong Univ, Frontier Inst Sci & Technol, Xian 710049, Peoples R China
  • [ 11 ] [Guo, Baolin]Xi An Jiao Tong Univ, Frontier Inst Sci & Technol, Xian 710049, Peoples R China
  • [ 12 ] [Qu, Jin]Xi An Jiao Tong Univ, State Key Lab Mech Behav Mat, Xian 710049, Peoples R China
  • [ 13 ] [Zhao, Xin]Xi An Jiao Tong Univ, State Key Lab Mech Behav Mat, Xian 710049, Peoples R China
  • [ 14 ] [Liang, Yongping]Xi An Jiao Tong Univ, State Key Lab Mech Behav Mat, Xian 710049, Peoples R China
  • [ 15 ] [Zhang, Tianlong]Xi An Jiao Tong Univ, State Key Lab Mech Behav Mat, Xian 710049, Peoples R China
  • [ 16 ] [Guo, Baolin]Xi An Jiao Tong Univ, State Key Lab Mech Behav Mat, Xian 710049, Peoples R China
  • [ 17 ] [Ma, Peter X.]Univ Michigan, Dept Biomed Engn, Ann Arbor, MI 48109 USA
  • [ 18 ] [Ma, Peter X.]Univ Michigan, Dept Biol & Mat Sci, Ann Arbor, MI 48109 USA
  • [ 19 ] [Ma, Peter X.]Univ Michigan, Macromol Sci & Engn Ctr, Ann Arbor, MI 48109 USA
  • [ 20 ] [Ma, Peter X.]Univ Michigan, Dept Mat Sci & Engn, Ann Arbor, MI 48109 USA

Reprint Author's Address:

  • Xi An Jiao Tong Univ, Frontier Inst Sci & Technol, Xian 710049, Peoples R China.; Guo, BL (reprint author), Xi An Jiao Tong Univ, State Key Lab Mech Behav Mat, Xian 710049, Peoples R China.

Show more details

Related Keywords:

Source :

BIOMATERIALS

ISSN: 0142-9612

Year: 2018

Volume: 183

Page: 185-199

1 0 . 2 7 3

JCR@2018

1 2 . 4 7 9

JCR@2020

ESI Discipline: MATERIALS SCIENCE;

ESI HC Threshold:182

JCR Journal Grade:2

CAS Journal Grade:1

Cited Count:

WoS CC Cited Count: 824

SCOPUS Cited Count: 1474

ESI Highly Cited Papers on the List: 20 Unfold All

  • 2022-11
  • 2022-9
  • 2022-7
  • 2022-5
  • 2022-3
  • 2022-1
  • 2021-11
  • 2021-9
  • 2021-7
  • 2021-5
  • 2021-3
  • 2021-1
  • 2020-11
  • 2020-9
  • 2020-7
  • 2020-5
  • 2020-03
  • 2020-1
  • 2019-11
  • 2019-9

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 10

FAQ| About| Online/Total:802/213535075
Address:XI'AN JIAOTONG UNIVERSITY LIBRARY(No.28, Xianning West Road, Xi'an, Shaanxi Post Code:710049) Contact Us:029-82667865
Copyright:XI'AN JIAOTONG UNIVERSITY LIBRARY Technical Support:Beijing Aegean Software Co., Ltd.