The　purpose　of　this　study　was　to　investigate　the　effects　of　dental　heat-pressing　on　the　microstructure　and　chemical　stability　of　a　novel　lithium　disilicate　glass-ceramic.　The　parent　glass　derived　from　SiO2-Li2O-K2O-Al2O3-ZrO2-P2O5system　was　melted　and　heat-treated.　Then　half　glass-ceramic　specimens　were　subjected　to　dental　heat-pressing.　The　crystalline　phase　composition　and　microstructures　were　analyzed　by　X-ray　diffractometry　(XRD)　and　scanning　electron　microscopy　(SEM).　Chemical　stability　of　glass-ceramic　specimens　was　measured　following　the　instruction　of　ISO　6872.　Results　demonstrated　that　lithium　disilicate　(Li2Si2O5)　represented　the　main　crystalline　phase　for　both　heat-pressed　and　controlled　specimens.　Increased　relative　intensities　of　major　peaks　and　prolonger　crystalline　size　were　observed　after　heat　pressing,　which　was　attributed　to　the　rearrangement　of　the　monoclinic　lithium　disilicate　crystals.　Heat-pressed　glass-ceramic　showed　stronger　resistance　to　chemical　corrosion.　Dental　heat-pressing　could　result　in　the　change　in　microstructure　and　improve　the　chemical　stability　of　experimental　glass-ceramic.