Six　types　of　conceptual　design　of　accelerator　driven　sub-critical　system　(ADS)　were　proposed　considering　the　effect　of　initial　plutonium　loading　for　ADS　to　transmute　minor　actinides.　In　the　specific　design,　uranium-free　metallic　dispersion　fuel　of　(TRU-10Zr)-Zr*was　used　as　the　fuel.　MCNP　and　ORIGEN2　codes　were　applied　to　the　neutron　simulation　and　burnup　calculation　for　ADS,　and　the　MA　transmutation　effect,　the　effective　multiplication　factor　keffand　proton　beam　current　corresponding　to　initial　plutonium　content　were　investigated.　The　results　show　that,　with　the　increase　of　the　initial　plutonium　content,　the　transmutation　rate　of　MA　decreases　and　the　initial　proton　beam　current　increases;　the　initial　plutonium　content　is　less　than　33%,　the　variation　of　the　effective　multiplication　factor　with　burnup　time　increases　at　first　and　then　decreases,　when　greater　than　33%,　it　decreases　all　the　time,　and　with　the　increase　of　the　initial　Pu　content,　keffdecreases　more　obviously.　Therefore,　33%　of　the　initial　plutonium　content　of　the　conceptual　design　is　chosen,　the　relative　change　of　keffis　less　than　1%,　the　proton　beam　current　is　less　than　20　mA,　the　transmutation　rate　of　MA　can　reach　28.06%,　and　support　ratio　of　MA　transmutation　can　reach　29.23.