©　2015,　Chinese　Nuclear　Society.　All　right　reserved.　Large　eddy　simulation　(LES)　with　1.12×108　meshes　was　performed　on　three-dimensional　jet　in　cross-flow(JICF)　using　lattice　Boltzmann　method　(LBM)　and　multiple　Graphic　Processing　Units　(Multi-GPUs).　Reynolds　number　based　on　free-stream　velocity　and　jet　diameter　is　4000,　streamwise　inclination　angle　of　jet　is　α=30°,　and　jet-to-cross-flow　velocity　ratio　is　set　as　0.5.　Validity　and　feasibility　of　LBM-LES　on　simulating　jet　in　cross-flow　were　verified　by　reasonable　qualitative　and　quantitative　results.　Fine　coherent　structures　were　captured　by　large-scaled　simulation　which　benefits　study　on　mixing　mechanism　of　jet-in-cross-flow　(JICF).　Moreover,　6　K20M　GPUs　were　adopted　in　simulation　and　it　took　15402　seconds　for　LBM-GPU　solver　to　simulate　71680　LBM　steps　resulting　in　calculated　performance　of　521.24　MLUPS.