Rationale:　Chronic　nonhealing　diabetic　wound　therapy　and　complete　skin　regeneration　remains　a　critical　clinical　challenge.　The　controlled　release　of　bioactive　factors　from　a　multifunctional　hydrogel　was　a　promising　strategy　to　repair　chronic　wounds.　Methods:　Herein,　for　the　first　time,　we　developed　an　injectable,　self-healing　and　antibacterial　polypeptide-based　FHE　hydrogel　(F127/OHA-EPL)　with　stimuli-responsive　adipose-derived　mesenchymal　stem　cells　exosomes　(AMSCs-exo)　release　for　synergistically　enhancing　chronic　wound　healing　and　complete　skin　regeneration.　The　materials　characterization,　antibacterial　activity,　stimulated　cellular　behavior　and　in　vivo　full-thickness　diabetic　wound　healing　ability　of　the　hydrogels　were　performed　and　analyzed.　Results:　The　FHE　hydrogel　possessed　multifunctional　properties　including　fast　self-healing　process,　shear-thinning　injectable　ability,　efficient　antibacterial　activity,　and　long　term　pH-responsive　bioactive　exosomes　release　behavior.　In　vitro,　the　FHE@exosomes　(FHE@exo)　hydrogel　significantly　promoted　the　proliferation,　migration　and　tube　formation　ability　of　human　umbilical　vein　endothelial　cells　(HUVECs).　In　vivo,　the　FHE@exo　hydrogel　significantly　enhanced　the　healing　efficiency　of　diabetic　full-thickness　cutaneous　wounds,　characterized　with　enhanced　wound　closure　rates,　fast　angiogenesis,　re-epithelization　and　collagen　deposition　within　the　wound　site.　Moreover,　the　FHE@exo　hydrogel　displayed　better　healing　outcomes　than　those　of　exosomes　or　FHE　hydrogel　alone,　suggesting　that　the　sustained　release　of　exosomes　and　FHE　hydrogel　can　synergistically　facilitate　diabetic　wound　healing.　Skin　appendages　and　less　scar　tissue　also　appeared　in　FHE@exo　hydrogel　treated　wounds,　indicating　its　potent　ability　to　achieve　complete　skin　regeneration.　Conclusion:　This　work　offers　a　new　approach　for　repairing　chronic　wounds　completely　through　a　multifunctional　hydrogel　with　controlled　exosomes　release.