Diabetic　wound　healing　and　angiogenesis　remain　a　worldwide　challenge　for　both　clinic　and　research.　The　use　of　adipose　stromal　cell　derived　exosomes　delivered　by　bioactive　dressing　provides　a　potential　strategy　for　repairing　diabetic　wounds　with　less　scar　formation　and　fast　healing.　In　this　study,　we　fabricated　an　injectable　adhesive　thermosensitive　multifunctional　polysaccharide-based　dressing　(FEP)　with　sustained　pH-responsive　exosome　release　for　promoting　angiogenesis　and　diabetic　wound　healing.　The　FEP　dressing　possessed　multifunctional　properties　including　efficient　antibacterial　activity/multidrug-resistant　bacteria,　fast　hemostatic　ability,　self-healing　behavior,　and　tissue-adhesive　and　good　UV-shielding　performance.　FEP@exosomes　(FEP@exo)　can　significantly　enhance　the　proliferation,　migration,　and　tube　formation　of　endothelial　cells　in　vitro.　In　vivo　results　from　a　diabetic　full-thickness　cutaneous　wound　model　showed　that　FEPpexo　dressing　accelerated　the　wound　healing　by　stimulating　the　angiogenesis　process　of　the　wound　tissue.　The　enhanced　cell　proliferation,　granulation　tissue　formation,　collagen　deposition,　remodeling,　and　re-epithelialization　probably　lead　to　the　fast　healing　with　less　scar　tissue　formation　and　skin　appendage　regeneration.　This　study　showed　that　combining　bioactive　molecules　into　multifunctional　dressing　should　have　great　potential　in　achieving　satisfactory　healing　in　diabetic　and　other　vascular-impaired　related　wounds.