Diabetic　wound　repair　and　skin　regeneration　remains　a　worldwide　challenge　due　to　the　impaired　functionality　of　re-vascularization.　Methods:　This　study　reports　a　bioactive　self-healing　antibacterial　injectable　dual-network　silica-based　nanocomposite　hydrogel　scaffolds　that　can　significantly　enhance　the　diabetic　wound　healing/skin　tissue　formation　through　promoting　early　angiogenesis　without　adding　any　bioactive　factors.　The　nanocomposite　scaffold　comprises　a　main　network　of　polyethylene　glycol　diacrylate　(PEGDA)　forming　scaffolds,　with　an　auxiliary　dynamic　network　formed　between　bioactive　glass　nanoparticles　containing　copper　(BGNC)　and　sodium　alginate　(ALG)　(PABC　scaffolds).　Results:　PABC　scaffolds　exhibit　the　biomimetic　elastomeric　mechanical　properties,　excellent　injectabilities,　self-healing　behavior,　as　well　as　the　robust　broad-spectrum　antibacterial　activity.　Importantly,　PABC　hydrogel　significantly　promoted　the　viability,　proliferation　and　angiogenic　ability　of　endothelial　progenitor　cells　(EPCs)　in　vitro.　In　vivo,　PABC　hydrogel　could　efficiently　restore　blood　vessels　networks　through　enhancing　HIF-1　alpha/VEGF　expression　and　collagen　matrix　deposition　in　the　full-thickness　diabetic　wound,　and　significantly　accelerate　wound　healing　and　skin　tissue　regeneration.　Conclusion:　The　prominent　multifunctional　properties　and　angiogenic　capacity　of　PABC　hydrogel　scaffolds　enable　their　promising　applications　in　angiogenesis-related　regenerative　medicine.