The　simultaneous　therapy　of　tumors　and　bone　defects　resulting　from　tumor　surgery　is　still　a　challenge　in　clinical　orthopedics.　Few　nanomaterial　systems　simultaneously　possess　multifunctional　capacities,　including　biodegradability,　tumor　treatment,　and　enhanced　bone　regeneration.　Herein,　we　designed　a　biodegradable　monodispersed　bioactive　glass　nanoparticle　(BGN)　platform　with　multifunctional　properties　for　enhanced　colon　cancer　photothermo-chemotherapy　and　bone　repair.　The　mussel-inspired　surface　assembly　with　BGN　was　established　as　a　stable　NIR-excited　photothermal　nanoplatform　(BGN@PDA)　for　ablating　tumors.　BGN@PDA　shows　an　ultrahigh　anticancer　drug　(DOX)　loading　with　on-demand　(pH/NIR-responsive)　drug　release　behavior　and　antibacterial　activity　for　enhanced　tumor　chemotherapy　(BGN@PDADOX).　The　growth　of　colon　cancer　cells　(Hct116　cells)　and　cervical　cancer　cells　(HeLa　cells)　was　significantly　inhibited　in　vitro,　and　superior　local　anticancer　efficacy　could　be　achieved　by　synergic　chemo-photothermal　therapy　in　vivo.　BGN@PDA　underwent　a　gradual　degradation　in　vivo　during　60　days　and　showed　negligible　toxic　side　effects.　Meanwhile,　BGN@PDA　could　positively　induce　the　osteogenesis　of　osteoblasts　in　vitro　and　possess　excellent　in　vivo　bone　repair　ability　in　rat　cranial　defects.　This　work　presents　a　distinctive　strategy　to　design　a　bioactive　multifunctional　nanoplatform　for　treating　tumor　disease-resulted　bone　tissue　regeneration.