Postsurgical　tumor　recurrence,　infection,　and　tissue　defect　are　still　the　challenges　in　clinical　medicine.　The　development　of　multifunctional　biomaterial　scaffolds　with　a　microenvironment-responsive　tumor-infection　therapy-tissue　repair　is　highly　desirable.　Herein,　we　report　a　bioactive,　injectable,　adhesive,　self-healing,　antibacterial,　and　anti-inflammatory　metal-polyphenol　polypeptide　nanocomposite　scaffold　(PEAPF)　with　temporal-spatial-controlled　inflammation-　triggered　therapeutic　properties　for　efficient　infection　and　postsurgical　tumor　therapy　and　skin　repair.　PEAPF　scaffolds　showed　sustained　and　inherent　inflammation-triggered　Fenton　catalysis　and　mild　thermochemical　effect　for　specifically　inhibiting　tumor　recurrence　in　vitro　and　in　vivo.　The　PEAPF　scaffolds　significantly　facilitated　skin　tissue　regeneration　in　MRSA-infected　chronic　wounds　and　postsurgical　tissue　defects　after　tumor　resection.　This　study　presents　the　multifunctional　scaffold-based　safe　and　efficient　therapeutic　strategy　to　prevent　local　tumor　recurrence　and　enhance　postsurgical　tissue　regeneration.