Traditional　hydrogel　dressings　are　limited　in　practical　applications　due　to　the　complexity　of　the　preparation　and　low　biocompatibility.　So,　there　is　an　urgent　need　to　design　wound　dressing　with　simple　preparation　method,　higher　biocompatibility,　and　superior　therapeutic　effect.　Additionally,　using　a　polysaccharide/protein　mixture　system　is　an　attractive　method　to　prepare　the　gel.　In　this　study,　a　simple　mixture　of　hyaluronic　acid/lysozyme　(HL)　was　used　to　obtain　the　HL　coacervate　gel.　HL　coacervate　has　suitable　viscoelasticity　and　excellent　adhesion　on　the　skin　tissue.　We　demonstrated　its　highly　efficient　self-healing　property　to　overcome　fracture　or　deformation.　HL　coacervate　showed　a　significant　effect　on　promoting　wound　healing　in　a　full-thickness　skin　defect　model.　Compared　to　the　commercial　3M　dressing,　it　has　faster　epithelial　tissue　regeneration　and　stronger　collagen　deposition.　In　addition,　cytotoxicity　and　organ　toxicity　tests　indicated　its　high　safety.　In　summary,　HL　coacervate　has　broad　clinical　application　prospects　as　a　wound　dressing　material.　©　2020　The　Royal　Society　of　Chemistry.