The　postoperative　tissue　healing　of　tumor　excision,　monitoring　of　remained　tumor　cells　and　inhibiting　of　tumor　recurrence　are　still　the　great　challenge.　Herein,　we　develop　a　multifunctional　biodegradable　silicon-based　Eu-Gd-Si-Ca　bioactive　glass　nanoplatform　(MBSGN)　for　tumor　imaging,　inhibiting　tumor　recurrence　and　enhancing　tumor-impaired　tissue　regeneration.　MBSGN　exhibited　a　branched　mesoporous　structure　(10–20　nm),　controlled　biodegradation,　ultrahigh　drug　loading　(602.52　mg　g−1)　and　pH　responsive　release　behavior,　special　magneto-optical　properties　and　tumor　cell-targeted　surface.　MBSGN　possessed　excellent　biocompatibility　and　tumor　cell-targeted　capacity　in　vitro.　MBSGN　showed　multi-model　bioimaging　capacity　for　skin　tumor　tissue　(fluorescence/magnetic　resonance/computed　tomography　imaging).　MBSGN　could　efficiently　eliminate　the　tumor　growth,　inhibit　the　local　tumor　recurrence　through　in　situ　removal　of　residual　tumor　cells,　greatly　enhance　the　full-thickness　wound　healing　and　tumor　surgery-caused　wounds　repair.　This　study　offers　a　reasonable　and　promising　pathway　for　in　situ　integration　of　multi-modal　bio-imaging,　recurrent　melanoma　therapy　and　tissue　regeneration.　©　2021　Elsevier　Ltd