The　complex　wound　repair　induced　by　tumor　surgery　and　infection　is　still　the　clinical　challenge　due　to　the　subsequent　tumor　recurrence　and　serious　inflammation.　Herein,　we　develop　a　bioactive　Si-Ca-Sr　glass-based　therapy-regeneration-enabled　nanohybrids　(BSr@PPE)　with　hierarchical　versatility　for　overcoming　the　challenges　of　tumor　and　infection-impaired　wound　repair.　BSr@PPE　showed　a　representative　concentration-dependent　photothermal　effect,　strong　free　radical　scavenging　and　antibacterial　ability,　as　well　as　good　UV-shielding　properties　and　high　biocompatibility.　BSr@PPE　could　efficiently　kill　tumor　cells　through　the　photothermal　effect,　show　the　robust　antibacterial　activity　against　normal　and　multi-drug　resistant　bacteria　and　enhance　the　fibroblasts　migration　in　vitro.　In　vivo　animal　experiments　suggested　that　BSr@PPE　could　effectively　promote　epithelial　reconstruction,　collagen　deposition　and　angiogenesis　in　normal　wounds,　reduce　inflammation　and　enhance　repair　in　multi-drug　bacterial　infected　wounds,　accelerate　the　tumor-impaired　wound　through　inhibit　the　tumor　cells.　This　work　may　provide　a　new　strategy　and　multifunctional　bioactive　material　for　treating　the　tissue　repair　and　regeneration　under　the　multi-pathological　environments.　©　2022　Elsevier　Ltd