Endoscopic　mucosal　resection　(EMR)　and　endoscopic　submucosal　dissection　(ESD)　are　well-established　therapeutics　for　gastrointestinal　neoplasias,　but　complications　after　EMR/ESD,　including　bleeding　and　perforation,　result　in　additional　treatment　morbidity　and　even　threaten　the　lives　of　patients.　Thus,　designing　biomaterials　to　treat　gastric　bleeding　and　wound　healing　after　endoscopic　treatment　is　highly　desired　and　remains　a　challenge.　Herein,　a　series　of　injectable　pH-responsive　self-healing　adhesive　hydrogels　based　on　acryloyl-6-aminocaproic　acid　(AA)　and　AA-g-N-hydroxysuccinimide　(AA-NHS)　were　developed,　and　their　great　potential　as　endoscopic　sprayable　bioadhesive　materials　to　efficiently　stop　hemorrhage　and　promote　the　wound　healing　process　was　further　demonstrated　in　a　swine　gastric　hemorrhage/wound　model.　The　hydrogels　showed　a　suitable　gelation　time,　an　autonomous　and　efficient　self-healing　capacity,　hemostatic　properties,　and　good　biocompatibility.　With　the　introduction　of　AA-NHS　as　a　micro-cross-linker,　the　hydrogels　exhibited　enhanced　adhesive　strength.　A　swine　gastric　hemorrhage　in　vivo　model　demonstrated　that　the　hydrogels　showed　good　hemostatic　performance　by　stopping　acute　arterial　bleeding　and　preventing　delayed　bleeding.　A　gastric　wound　model　indicated　that　the　hydrogels　showed　excellent　treatment　effects　with　significantly　enhanced　wound　healing　with　type　I　collagen　deposition,　α-SMA　expression,　and　blood　vessel　formation.　These　injectable　self-healing　adhesive　hydrogels　exhibited　great　potential　to　treat　gastric　wounds　after　endoscopic　treatment.[Figure　not　available:　see　fulltext.]　©　2021,　The　Author(s).