Endoscopic　submucosal　dissection　(ESD)　is　one　of　the　most　important　strategies　for　early　gastrointestinal　tumor　treatment.　However,　the　ideal　healing　of　artificial　ulcers　produced　after　ESD　procedure　are　still　hard　to　achieve.　In　a　gastric　ulcer　environment,　the　inherent　peristole,　acid　condition　and　excessive　oxidative　stress　seriously　affect　the　therapeutic　outcome　of　traditional　medication.　Curcumin　(Cur)　is　a　promising　anti-inflammatory　drug　for　gastric　ulcer　treatment,　but　its　long-term　use　is　still　challenging.　A　polymer-assisted　drug　delivery　system　in　gastrointestinal　disease　treatment　is　a　new　direction　but　is　still　at　an　initial　stage.　Herein,　we　report　a　hybrid　hydrogel　consisting　of　catechol　motif-modified　methacrylated　gelatin　(GelMAc)　and　methacrylated　poly　(vinyl　alcohol)　(PVAMA).　GelMAc　brought　significant　adhesive　property　and　biocompatibility.　PVAMA　could　effectively　provide　stability　and　mechanical　strength.　Moreover,　mesoporous　polydopamine　nanoparticles　were　prepared　as　the　drug　carrier　to　load　Cur　via　π-π　stacking　and　hydrogen　bonding　interactions,　and　they　were　encapsulated　in　the　hybrid　GelMAc/PVAMA　hydrogel.　The　prepared　sample　was　proved　to　have　a　unique　stability　on　gastric　tissue　even　bearing　acid　(pH　2)　and　oxidative　stress　(H2O2)　conditions.　The　slowly　released　Cur　from　the　hydrogel　was　capable　of　inducing　M2　polarization　of　macrophages.　In　an　in　vivo　gastric　ulcer　model,　the　prepared　sample　remarkably　improved　gastric　ulcer　healing　by　curbing　the　pro-inflammatory　response　and　alleviating　oxidative　stress.　An　accelerated　reepithelization　and　angiogenesis　were　also　observed.　Thus,　this　study　provides　a　promising　hydrogel　for　the　treatment　of　ESD-induced　ulcers,　which　may　attract　more　attentions　to　explore　the　deeper　combination　between　biomaterials　and　gastrointestinal　research.　©　2022　Elsevier　Ltd