Poly(vinyl　alcohol)　(PVA)　hydrogels　have　been　extensively　studied　as　drug　delivery　systems.　However,　due　to　the　high　hydrophilicity　of　PVA,　these　hydrogels　have　weak　abilities　to　efficiently　load　drugs　and　control　the　initial　burst　release.　In　this　study,　we　present　a　one-step　simple　and　rapid　single　needle　electrospraying　(SNESy)　method　that　combines　PVA　hydrogels　with　another　biocompatible　polymer　polycaprolactone　(PCL).　A　distinct　core-shell　structure　was　obtained　with　the　PVA　hydrogel　core　and　PCL　shell　after　the　system　was　properly　set　up.　The　results　revealed　that　the　volume　ratio　between　PVA　hydrogel　and　PCL　played　an　important　role　in　determining　the　particle　size　and　the　formation　of　a　spherical　structure.　The　double-walled　structure　of　the　microsphere　was　confirmed　by　taking　the　fluorescent　images　and　conducting　the　ATR-FTIR　method.　Furthermore,　doxorubicin　hydrochloride　was　used　as　a　model　drug　to　evaluate　the　drug　loading　capacity　and　the　in　vitro　release　behavior　of　this　PVA　hydrogel/PCL　microsphere.　The　results　indicated　that　coating　a　layer　of　PCL　polymer　significantly　enhanced　the　drug　loading　capacity　and　reduced　the　drug　initial　burst　release　compared　to　the　single-layer　PVA　hydrogel　nanoparticles,　demonstrating　these　biocompatible　double-walled　microspheres　can　be　applied　as　excellent　drug　delivery　carriers.　©　2019　Elsevier　B.V.