Local　tumor　therapy　through　injectable　biodegradable　hydrogels　with　controlled　drug　release　has　attracted　much　attention　recently,　due　to　their　easy　operation,　low　side　effect　and　efficiency.　However,　most　of　the　reported　therapeutic　hydrogel　system　showed　a　lack　of　biodegradation　tracking　and　tumor　environment-responsive　degradation/therapy.　Herein,　we　developed　a　multifunctional　injectable　biodegradation-visual　citric　acid-based　self-healing　scaffolds　with　microenvironment-responsive　degradation　and　drug　release　for　safe　and　efficient　skin　tumor　therapy　(FPRC　hydrogel).　FPRC　scaffolds　possess　multifunctional　properties　including　thermosensitive,　injectable,　self-healing,　photoluminescent　and　pH-responsive　degradation/drug　release.　The　FPRC　scaffolds　with　strong　red　fluorescence　which　has　good　photostability,　tissue　penetration　and　biocompatibility　can　be　tracked　and　monitored　to　evaluate　the　degradation　of　the　scaffolds　in　vivo.　Moreover,　the　FPRC　scaffolds　showed　pH-responsive　doxorubicin　(DOX)　release,　efficiently　killed　the　A375　cancer　cell　in　vitro　and　suppressed　the　tumor　growth　in　vivo.　Compared　to　the　free　drug　(DOX),　the　FPRC@DOX　scaffolds　displayed　a　significantly　high　therapeutic　effect　and　less　biotoxicity.　This　work　provides　an　alternative　strategy　to　design　smart　visual　scaffolds　for　tumor　therapy　and　regenerative　medicine.　©　2020　Elsevier　Ltd