Magnetron　sputtering　technique　was　employed　to　synthesize　crystalline/amorphous　high-entropy　alloy　(AHEA)　X/AHEA　(X　=　Cu　and　Ni,　AHEA　=　Fe20Co20Cr20Ni20B10Si10)　nanostructured　multilayers　(CANMs)　with　equal　layer　thickness　h　ranging　from　5　to　150　nm,　aiming　at　systematically　investigating　their　plastic　deformation　and　microstructural　evolution.　Unlike　traditional　crystalline/crystalline　multilayers　often　with　shear　banding　at　small　h,　the　present　X/AHEA　CANMs　exhibit　h-independent　homogeneous　deformation　via　the　thinning　of　both　constituent　layers,　while　associated　with　h-dependent　deformation-induced　devitrification　in　AHEA　layers　with　thickness　below　25　nm.　This　homogeneous　plasticity　of　AHEA　layers　with　the　large　incubation　size　for　mature　shear　bands　can　be　ascribed　to　the　coupling　between　dislocations　in　X　layers　and　shear　transformation　zones　in　AHEA　layers.　Meanwhile,　the　absorption　of　abundant　dislocations　emitted　from　X　layers　by　AHEA　layers　with　small　thickness　facilitates　the　occurrence　of　devitrification　behavior,　implying　the　microstructural　instability　under　strong　constraint　conditions.　Moreover,　both　of　Cu/AHEA　and　Ni/AHEA　CANMs　manifest　size-dependent　hardness　with　the　fashion　that　＂smaller　is　stronger＂,　which　is　captured　well　by　the　rule-of-mixture,　based　on　the　size-dependent　strength　of　X　nanolayers　and　size-independent　homogenous　flow　of　AHEA　nanolayers.