This　report　presents　a　case　of　the　application　of　a　customized　three-dimensional　(3D)　printed　pelvic　prosthesis　for　the　treatment　of　pelvic　malignant　tumor　in　one　patient.　The　pelvic　mass　was　scanned　by　computer　tomography　(CT)　to　obtain　two-dimensional　data　and　a　3D　digital　model　was　reconstructed　using　Mimics　software.　The　physical　model　was　then　printed　using　a　3D　printer.　The　tumor　resection　procedure　was　pre-designed　with　the　personalized　pelvic　prosthesis　prefabricated.　After　the　tumor　was　removed,　the　pelvic　prosthesis　was　successfully　implanted　and　an　artificial　total　hip　replacement　and　pelvis　and　hip　joint　reconstruction　were　performed　to　restore　the　shape　and　function　of　the　patient＇s　pelvis　and　hip　joint.　At　the　6-month　follow-up,　the　X-ray　results　indicated　that　the　prosthesis　and　the　pelvis　matched　well.　The　application　of　computer-aided　design　and　3D　printed　customdesigned　pelvic　prosthesis　for　the　treatment　of　pelvic　tumors　may　be　a　viable　method　for　a　more　accurate,　reliable,　convenient　surgery,　with　a　better　clinical　outcome.