Objective:　To　investigate　the　biocompatibility　of　Sr-containing　calcium　phosphate　cement　series　[SrHPO4/Ca4　(PO4)　2O/CaHPO4].　Methods:　A　series　tests,　including　acute　systemic　toxicity　test,　pyrogen　test,　hemolysis　test,　cytotoxicity　test　and　in　vitro　biological　behavior　of　osteoblasts,　were　designed　to　evaluate　the　cytobiology　of　the　material.　Results:　Sr-containing　calcium　phosphate　cement　had　excellent　biocompatibility　and　all　of　the　biological　evaluation　tests　were　up　to　the　standard.　Pyrogen　test,　hemolysis　test　and　ALP　value　of　Sr-containing　calcium　phosphate　cement　behavior　had　non-linear　relationships　with　the　Sr-doped　content.　Conclusion:　Sr-containing　calcium　phosphate　cement　series　are　good　in　biocompatibility　and　can　be　widely　used　in　tissue　engineering　research.