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Author:

Zhang, Hai-long (Zhang, Hai-long.) | Mi, Jie (Mi, Jie.) | Peng, Ya-jie (Peng, Ya-jie.) | Wang, Zhi-gang (Wang, Zhi-gang.) | Liu, Ying (Liu, Ying.) | Gao, Yang (Gao, Yang.)

Indexed by:

SCIE Scopus

Abstract:

A new semiterpenoid glycoside, 3-methylbutan-1, 3-diol-1-O-beta-D-glucopyranoside (1) and a new benzofuran derivative glycoside,6-carboxylethyl-benzofuran-5-O-beta-D-xylopyranosyl-(1 -> 2)-beta-D-glucopyranoside (2), together with seven known compounds (3-9) were isolated from the roots of Heracleum dissectum Ledeb. Their structures were elucidated on the basis of physicochemical properties and the detailed interpretation of various spectroscopic data. All the isolated compounds were screened for anti-inflammatory activity in vitro. And the result showed that compound 2 exhibited significantly inhibitory activity on nitric oxide production in RAW264.7 cells, which IC50 value was equivalent to that of the positive control indomethacin.

Keyword:

Anti-inflammation Benzofuran derivative glycoside Ethnic herb Heracleum dissectum Semiterpenoid glycosid

Author Community:

  • [ 1 ] [Zhang, Hai-long; Mi, Jie; Peng, Ya-jie; Gao, Yang] Xi An Jiao Tong Univ, Sch Pharm, Hlth Sci Ctr, Xian 710061, Shaanxi, Peoples R China
  • [ 2 ] [Wang, Zhi-gang] Heilongjiang Univ Chinese Med, Dept Pharmaceut Anal, Natl TCM Key Lab Serum Pharmacochem, Harbin 150040, Heilongjiang, Peoples R China
  • [ 3 ] [Liu, Ying] Chinese Acad Med Sci, State Key Lab Bioact Subst & Funct Nat Med, Inst Mat Med, Beijing, Peoples R China
  • [ 4 ] [Liu, Ying] Peking Union Med Coll, Beijing, Peoples R China
  • [ 5 ] [Zhang, Hai-long]Xi An Jiao Tong Univ, Sch Pharm, Hlth Sci Ctr, Xian 710061, Shaanxi, Peoples R China
  • [ 6 ] [Mi, Jie]Xi An Jiao Tong Univ, Sch Pharm, Hlth Sci Ctr, Xian 710061, Shaanxi, Peoples R China
  • [ 7 ] [Peng, Ya-jie]Xi An Jiao Tong Univ, Sch Pharm, Hlth Sci Ctr, Xian 710061, Shaanxi, Peoples R China
  • [ 8 ] [Gao, Yang]Xi An Jiao Tong Univ, Sch Pharm, Hlth Sci Ctr, Xian 710061, Shaanxi, Peoples R China
  • [ 9 ] [Wang, Zhi-gang]Heilongjiang Univ Chinese Med, Dept Pharmaceut Anal, Natl TCM Key Lab Serum Pharmacochem, Harbin 150040, Heilongjiang, Peoples R China
  • [ 10 ] [Liu, Ying]Chinese Acad Med Sci, State Key Lab Bioact Subst & Funct Nat Med, Inst Mat Med, Beijing, Peoples R China
  • [ 11 ] [Liu, Ying]Peking Union Med Coll, Beijing, Peoples R China

Reprint Author's Address:

  • Xi An Jiao Tong Univ, Sch Pharm, Hlth Sci Ctr, Xian 710061, Shaanxi, Peoples R China.

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Source :

PHYTOCHEMISTRY LETTERS

ISSN: 1874-3900

Year: 2017

Volume: 21

Page: 256-259

1 . 5 7 5

JCR@2017

1 . 6 7 9

JCR@2020

ESI Discipline: PLANT & ANIMAL SCIENCE;

ESI HC Threshold:88

JCR Journal Grade:3

CAS Journal Grade:4

Cited Count:

WoS CC Cited Count: 1

SCOPUS Cited Count: 3

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 13

Affiliated Colleges:

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